WebThe Forkhead box m1 (Foxm1) gene is critical for G (1)/S transition and essential for mitotic progression. However, the transcriptional mechanisms downstream of FoxM1 that control these cell cycle events remain to be determined. WebFeb 17, 2024 · FOXM1 gene is overexpressed in a variety of solid tumors 22. FOXM1 overexpression is often associated with an increased proliferation of tumor cells in lung, colon, prostate, and liver 22.
Novel FOXM1 inhibitor identified via gene network analysis ... - Nature
WebMar 21, 2024 · FOXM1 (Forkhead Box M1) is a Protein Coding gene. Diseases associated with FOXM1 include Hepatocellular Carcinoma and Protein C Deficiency . Among its related pathways are Loss of Nlp from mitotic centrosomes and Cell Cycle, Mitotic . WebMay 7, 2024 · To test specifically whether FOXM1 is necessary for FGF2-induced expression of cell cycle–regulated genes, fibroblasts were transfected with FOXM1 siRNA prior to stimulation with FGF2. The degree of knockdown of basal FOXM1 with 24 hours of siRNA was approximately 56 % ( Figure 2F ). shook boys
IJMS Free Full-Text Predicting FOXM1-Mediated Gene Regulation ...
WebOct 5, 2024 · Forkhead box M1 (FoxM1) played an important role in the pathogenesis of ovarian cancer, but its downstream molecular network is mysterious. Here, we combined ChIP-seq with RNA-seq analysis and identified 687 FoxM1-binding regions and 182 genes regulated by FoxM1. The above data pointed out that KRT5 and KRT7 were … WebDec 1, 2013 · We identify 2140 transcripts mapping to 1871 unique cell cycle–regulated genes and analyze FOXM1 genomic loci by genome-wide chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq). We show that FOXM1 is bound to many genes involved in the G2- to M-phase transition, as well as a number of genes … WebNov 29, 2024 · RNA-Seq analysis of the effects of compounds and of siFOXM1 on global FOXM1 gene regulation. We next used RNA-Seq to examine the effects of these … shook branch beach hampton tn